<?xml version="1.0" encoding="UTF-8"?>

<Bundle xmlns="http://hl7.org/fhir">
  <id value="GenomicsOrderMessage-ctDNA"/>
  <meta>
    <profile value="https://fhir.nwgenomics.nhs.uk/StructureDefinition/BundleMessage"/>
  </meta>
  <language value="en"/>
  <identifier>
    <system value="urn:ietf:rfc:3986"/>
    <value value="urn:uuid:1aa724a8-981e-488e-9e6b-7a73e7c3c07a"/>
  </identifier>
  <type value="message"/>
  <timestamp value="2025-10-14T15:59:16+00:00"/>
  <entry>
    <fullUrl value="urn:uuid:72d8c754-ebd0-4e3c-b6e1-4d99cadb7f50"/>
    <resource>
      <MessageHeader>
        <id value="MessageHeaderO21ctDNA"/>
        <meta>
          <lastUpdated value="2026-07-13T10:39:26+00:00"/>
          <profile value="https://fhir.nwgenomics.nhs.uk/StructureDefinition/MessageHeader"/>
        </meta>
        <language value="en"/>
        <text>
          <status value="generated"/><div xmlns="http://www.w3.org/1999/xhtml"><a name="MessageHeader_MessageHeaderO21ctDNA"> </a><p class="res-header-id"><b>Generated Narrative: MessageHeader MessageHeaderO21ctDNA</b></p><a name="MessageHeaderO21ctDNA"> </a><a name="hcMessageHeaderO21ctDNA"> </a><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Last updated: 2026-07-13 10:39:26+0000</p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-MessageHeader.html">Document Message (MessageHeader)</a></p></div><p><b>event</b>: <a href="http://terminology.hl7.org/7.2.0/CodeSystem-v2-0003.html#v2-0003-O21">event: O21</a> (OML - Laboratory order)</p><h3>Destinations</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Endpoint</b></td><td><b>Receiver</b></td></tr><tr><td style="display: none">*</td><td><a href="https://simplifier.net/resolve?scope=fhir.r4.ukcore.stu3.currentbuild@0.29.0-pre-release&amp;canonical=https://fhir.nwgenomics.nhs.uk/Endpoint/NEYAWSSQS">https://fhir.nwgenomics.nhs.uk/Endpoint/NEYAWSSQS</a></td><td>NEY GMSA (Identifier: <a href="NamingSystem-ods-organization-code-namingsystem.html" title="The identifier system for an Organisation registered with the Organisation Data Service (ODS).">ODS Organisation Code</a>/699N0)</td></tr></table><p><b>sender</b>: Identifier: <a href="NamingSystem-ods-organization-code-namingsystem.html" title="The identifier system for an Organisation registered with the Organisation Data Service (ODS).">ODS Organisation Code</a>/699X0</p><h3>Sources</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Software</b></td><td><b>Endpoint</b></td></tr><tr><td style="display: none">*</td><td>NW GMSA</td><td><a href="https://simplifier.net/resolve?scope=fhir.r4.ukcore.stu3.currentbuild@0.29.0-pre-release&amp;canonical=https://fhir.nwgenomics.nhs.uk/Endpoint/iGene">https://fhir.nwgenomics.nhs.uk/Endpoint/iGene</a></td></tr></table><p><b>focus</b>: <a href="Bundle-FHIRDocumentGeneticReportBundle-ctDNA.html#urn-uuid-6e26d6b3-490e-4348-9d6c-37281567d6ec">ServiceRequest Non-Small Cell Lung Cancer, Multi-target ctDNA combined Multi-target NGS panel, small variant (EGFR, ALK, BRAF, KRAS, MET exon 14 skipping and copy number variations) and structural variant (ROS1, RET, ALK, NTRK1, NTRK2, NTRK3, MET exon</a></p></div>
        </text>
        <eventCoding>
          <system value="http://terminology.hl7.org/CodeSystem/v2-0003"/>
          <code value="O21"/>
        </eventCoding>
        <destination>
          <endpoint value="https://fhir.nwgenomics.nhs.uk/Endpoint/NEYAWSSQS"/>
          <receiver>
            <identifier>
              <system value="https://fhir.nhs.uk/Id/ods-organization-code"/>
              <value value="699N0"/>
            </identifier>
            <display value="NEY GMSA"/>
          </receiver>
        </destination>
        <sender>
          <identifier>
            <system value="https://fhir.nhs.uk/Id/ods-organization-code"/>
            <value value="699X0"/>
          </identifier>
        </sender>
        <source>
          <software value="NW GMSA"/>
          <endpoint value="https://fhir.nwgenomics.nhs.uk/Endpoint/iGene"/>
        </source>
        <focus>
          <reference value="urn:uuid:6e26d6b3-490e-4348-9d6c-37281567d6ec"/>
          <type value="ServiceRequest"/>
        </focus>
      </MessageHeader>
    </resource>
  </entry>
  <entry>
    <fullUrl value="urn:uuid:2160525b-0168-4f40-8ebf-9b053052a62c"/>
    <resource>
      <Patient>
        <id value="Patient-Sheffield"/>
        <meta>
          <profile value="https://fhir.nwgenomics.nhs.uk/StructureDefinition/Patient"/>
        </meta>
        <language value="en"/>
        <text>
          <status value="generated"/><div xmlns="http://www.w3.org/1999/xhtml"><a name="Patient_Patient-Sheffield"> </a><p class="res-header-id"><b>Generated Narrative: Patient Patient-Sheffield</b></p><a name="Patient-Sheffield"> </a><a name="hcPatient-Sheffield"> </a><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px"/><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-Patient.html">Patient</a></p></div><p style="border: 1px #661aff solid; background-color: #e6e6ff; padding: 10px;">Theon SHEFFIELD (official) Male, DoB: 1986-09-12 ( Patient internal identifier)</p><hr/><table class="grid"><tr><td style="background-color: #f3f5da" title="Record is active">Active:</td><td colspan="3">true</td></tr><tr><td style="background-color: #f3f5da" title="Other Id (see the one above)">Other Id:</td><td colspan="3">National Health Plan Identifier/9737873858 (use: official, )</td></tr><tr><td style="background-color: #f3f5da" title="Ways to contact the Patient">Contact Detail</td><td colspan="3">SPITAL STREET SHEFFIELD S3 9LB (home)</td></tr><tr><td style="background-color: #f3f5da" title="Patient Links">Links:</td><td colspan="3"><ul><li>General Practitioner: Sheffield Medical Centre (Identifier: <a href="NamingSystem-ods-organization-code-namingsystem.html" title="The identifier system for an Organisation registered with the Organisation Data Service (ODS).">ODS Organisation Code</a>/C88622)</li></ul></td></tr></table></div>
        </text>
        <identifier>
          <use value="official"/>
          <type>
            <coding>
              <system value="http://terminology.hl7.org/CodeSystem/v2-0203"/>
              <code value="NH"/>
            </coding>
          </type>
          <system value="https://fhir.nhs.uk/Id/nhs-number"/>
          <value value="9737873858"/>
        </identifier>
        <identifier>
          <type>
            <coding>
              <system value="http://terminology.hl7.org/CodeSystem/v2-0203"/>
              <code value="PI"/>
            </coding>
          </type>
          <value value="336292"/>
          <assigner>
            <identifier>
              <system value="https://fhir.nhs.uk/Id/ods-organization-code"/>
              <value value="699X0"/>
            </identifier>
          </assigner>
        </identifier>
        <active value="true"/>
        <name>
          <use value="official"/>
          <family value="SHEFFIELD"/>
          <given value="Theon"/>
        </name>
        <gender value="male"/>
        <birthDate value="1986-09-12"/>
        <address>
          <use value="home"/>
          <type value="both"/>
          <line value="SPITAL STREET"/>
          <city value="SHEFFIELD"/>
          <postalCode value="S3 9LB"/>
        </address>
        <generalPractitioner>
          <identifier>
            <system value="https://fhir.nhs.uk/Id/ods-organization-code"/>
            <value value="C88622"/>
          </identifier>
          <display value="Sheffield Medical Centre"/>
        </generalPractitioner>
      </Patient>
    </resource>
  </entry>
  <entry>
    <fullUrl value="urn:uuid:6e26d6b3-490e-4348-9d6c-37281567d6ec"/>
    <resource>
      <ServiceRequest>
        <id value="ServiceRequest-ctDNA"/>
        <meta>
          <versionId value="1.0"/>
          <profile value="https://fhir.nwgenomics.nhs.uk/StructureDefinition/ServiceRequest"/>
        </meta>
        <language value="en"/>
        <text>
          <status value="generated"/><div xmlns="http://www.w3.org/1999/xhtml"><a name="ServiceRequest_ServiceRequest-ctDNA"> </a><p class="res-header-id"><b>Generated Narrative: ServiceRequest ServiceRequest-ctDNA</b></p><a name="ServiceRequest-ctDNA"> </a><a name="hcServiceRequest-ctDNA"> </a><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">version: 1.0</p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-ServiceRequest.html">ServiceRequest</a></p></div><p><b>identifier</b>: Filler Identifier/T26-59XG</p><p><b>requisition</b>: Placer Group Number/R26-15AY</p><p><b>status</b>: Active</p><p><b>intent</b>: Order</p><p><b>category</b>: <span title="Codes:{http://snomed.info/sct 116148004}">Molecular genetics procedure</span></p><p><b>code</b>: <span title="Codes:{https://fhir.nhs.uk/CodeSystem/England-GenomicTestDirectory M4.14}">Non-Small Cell Lung Cancer, Multi-target ctDNA combined Multi-target NGS panel, small variant (EGFR, ALK, BRAF, KRAS, MET exon 14 skipping and copy number variations) and structural variant (ROS1, RET, ALK, NTRK1, NTRK2, NTRK3, MET exon</span></p><p><b>subject</b>: <a href="Bundle-FHIRDocumentGeneticReportBundle-ctDNA.html#urn-uuid-2160525b-0168-4f40-8ebf-9b053052a62c">Theon SHEFFIELD</a></p><p><b>requester</b>: Identifier: <a href="NamingSystem-ods-organization-code-namingsystem.html" title="The identifier system for an Organisation registered with the Organisation Data Service (ODS).">ODS Organisation Code</a>/RHQ</p><p><b>performer</b>: Identifier: <a href="NamingSystem-ods-organization-code-namingsystem.html" title="The identifier system for an Organisation registered with the Organisation Data Service (ODS).">ODS Organisation Code</a>/699X0</p><p><b>reasonCode</b>: <span title="Codes:{https://fhir.nwgenomics.nhs.uk/CodeSystem/GenomicClinicalIndication M4}">M4</span></p><p><b>specimen</b>: <a href="Bundle-FHIRDocumentGeneticReportBundle-ctDNA.html#urn-uuid-b930b4c4-327a-4728-8bb9-f90061914cc5">Specimen: identifier = Filler Identifier; status = available; type = Blood specimen</a></p></div>
        </text>
        <identifier>
          <type>
            <coding>
              <system value="http://terminology.hl7.org/CodeSystem/v2-0203"/>
              <code value="FILL"/>
            </coding>
          </type>
          <system value="https://fhir.nwgenomics.nhs.uk/iGene/ReportIdentifier"/>
          <value value="T26-59XG"/>
          <assigner>
            <identifier>
              <system value="https://fhir.nhs.uk/Id/ods-organization-code"/>
              <value value="699X0"/>
            </identifier>
          </assigner>
        </identifier>
        <requisition>
          <type>
            <coding>
              <system value="http://terminology.hl7.org/CodeSystem/v2-0203"/>
              <code value="PGN"/>
            </coding>
          </type>
          <system value="https://fhir.nwgenomics.nhs.uk/iGene/ReferralIdentifier"/>
          <value value="R26-15AY"/>
          <assigner>
            <identifier>
              <system value="https://fhir.nhs.uk/Id/ods-organization-code"/>
              <value value="699X0"/>
            </identifier>
          </assigner>
        </requisition>
        <status value="active"/>
        <intent value="order"/>
        <category>
          <coding>
            <system value="http://snomed.info/sct"/>
            <code value="116148004"/>
            <display value="Molecular genetics procedure"/>
          </coding>
        </category>
        <code>
          <coding>
            <system value="https://fhir.nhs.uk/CodeSystem/England-GenomicTestDirectory"/>
            <code value="M4.14"/>
          </coding>
        </code>
        <subject>
          <reference value="urn:uuid:2160525b-0168-4f40-8ebf-9b053052a62c"/>
          <identifier>
            <system value="https://fhir.nhs.uk/Id/nhs-number"/>
            <value value="9737873858"/>
          </identifier>
          <display value="Theon SHEFFIELD"/>
        </subject>
        <requester>
          <type value="Organization"/>
          <identifier>
            <system value="https://fhir.nhs.uk/Id/ods-organization-code"/>
            <value value="RHQ"/>
          </identifier>
        </requester>
        <performer>
          <type value="Organization"/>
          <identifier>
            <system value="https://fhir.nhs.uk/Id/ods-organization-code"/>
            <value value="699X0"/>
          </identifier>
        </performer>
        <reasonCode>
          <coding>
            <system value="https://fhir.nwgenomics.nhs.uk/CodeSystem/GenomicClinicalIndication"/>
            <code value="M4"/>
          </coding>
        </reasonCode>
        <specimen>
          <reference value="urn:uuid:b930b4c4-327a-4728-8bb9-f90061914cc5"/>
        </specimen>
      </ServiceRequest>
    </resource>
  </entry>
  <entry>
    <fullUrl value="urn:uuid:b930b4c4-327a-4728-8bb9-f90061914cc5"/>
    <resource>
      <Specimen>
        <id value="Specimen-ctDNA"/>
        <meta>
          <versionId value="1.0"/>
          <profile value="https://fhir.nwgenomics.nhs.uk/StructureDefinition/Specimen"/>
        </meta>
        <language value="en"/>
        <text>
          <status value="generated"/><div xmlns="http://www.w3.org/1999/xhtml"><a name="Specimen_Specimen-ctDNA"> </a><p class="res-header-id"><b>Generated Narrative: Specimen Specimen-ctDNA</b></p><a name="Specimen-ctDNA"> </a><a name="hcSpecimen-ctDNA"> </a><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">version: 1.0</p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-Specimen.html">Specimen</a></p></div><p><b>identifier</b>: Filler Identifier/S26-1K1Q</p><p><b>status</b>: Available</p><p><b>type</b>: <span title="Codes:{http://snomed.info/sct 119297000}">Blood specimen</span></p><p><b>subject</b>: <a href="Bundle-FHIRDocumentGeneticReportBundle-ctDNA.html#urn-uuid-2160525b-0168-4f40-8ebf-9b053052a62c">Theon SHEFFIELD</a></p><h3>Collections</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Collected[x]</b></td></tr><tr><td style="display: none">*</td><td>2026-06-29</td></tr></table></div>
        </text>
        <identifier>
          <type>
            <coding>
              <system value="http://terminology.hl7.org/CodeSystem/v2-0203"/>
              <code value="FILL"/>
            </coding>
          </type>
          <system value="https://fhir.nwgenomics.nhs.uk/iGene/SpecimenIdentifier"/>
          <value value="S26-1K1Q"/>
          <assigner>
            <identifier>
              <system value="https://fhir.nhs.uk/Id/ods-organization-code"/>
              <value value="699X0"/>
            </identifier>
          </assigner>
        </identifier>
        <status value="available"/>
        <type>
          <coding>
            <system value="http://snomed.info/sct"/>
            <code value="119297000"/>
            <display value="Blood specimen"/>
          </coding>
        </type>
        <subject>
          <reference value="urn:uuid:2160525b-0168-4f40-8ebf-9b053052a62c"/>
          <identifier>
            <system value="https://fhir.nhs.uk/Id/nhs-number"/>
            <value value="9737873858"/>
          </identifier>
          <display value="Theon SHEFFIELD"/>
        </subject>
        <collection>
          <collectedDateTime value="2026-06-29"/>
        </collection>
      </Specimen>
    </resource>
  </entry>
</Bundle>