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: Molecular Consequence - Loss of Heterozygosity (BRCA1)

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<Observation xmlns="http://hl7.org/fhir">
  <id value="ctdna9737383222-seqv1-loh"/>
  <meta>
    <profile
             value="https://fhir.nwgenomics.nhs.uk/StructureDefinition/MolecularConsequence"/>
  </meta>
  <language value="en"/>
  <text>
    <status value="generated"/>
    <div xmlns="http://www.w3.org/1999/xhtml"><p class="res-header-id"><b>Generated Narrative: Observation ctdna9737383222-seqv1-loh</b></p><a name="ctdna9737383222-seqv1-loh"> </a><a name="hcctdna9737383222-seqv1-loh"> </a><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px"/><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-MolecularConsequence.html">Molecular Consequence (Observation)</a></p></div><p><b>identifier</b>: ctdna9737383222-seqv1-loh</p><p><b>status</b>: Final</p><p><b>category</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}">Genetics</span>, <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span></p><p><b>code</b>: <span title="Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs molecular-consequence}">Molecular Consequence</span></p><p><b>subject</b>: <a href="Patient-Patient-Leeds.html">Rob LEEDS (official) Male, DoB: 1978-01-17 ( Medical record number)</a></p><p><b>effective</b>: 2026-07-14 15:59:16+0000</p><p><b>performer</b>: <a href="PractitionerRole-59577028-8fcc-4554-8b43-988561d41d9c.html">PractitionerRole</a></p><p><b>derivedFrom</b>: <a href="Observation-ctdna9737383222-seqv1.html">Observation Genetic variant assessment</a></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs functional-effect}">Functional Effect</span></td><td><span title="Codes:{http://www.sequenceontology.org SO_0001786}">loss_of_heterozygosity</span></td></tr></table></div>
  </text>
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    <value value="ctdna9737383222-seqv1-loh"/>
  </identifier>
  <status value="final"/>
  <category>
    <coding>
      <system value="http://terminology.hl7.org/CodeSystem/v2-0074"/>
      <code value="GE"/>
      <display value="Genetics"/>
    </coding>
  </category>
  <category>
    <coding>
      <system
              value="http://terminology.hl7.org/CodeSystem/observation-category"/>
      <code value="laboratory"/>
    </coding>
  </category>
  <code>
    <coding>
      <system
              value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
      <code value="molecular-consequence"/>
    </coding>
  </code>
  <subject>🔗 
    <reference value="Patient/Patient-Leeds"/>
  </subject>
  <effectiveDateTime value="2026-07-14T15:59:16+00:00"/>
  <performer>🔗 
    <reference value="PractitionerRole/59577028-8fcc-4554-8b43-988561d41d9c"/>
  </performer>
  <derivedFrom>🔗 
    <reference value="Observation/ctdna9737383222-seqv1"/>
  </derivedFrom>
  <component>
    <code>
      <coding>
        <system
                value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
        <code value="functional-effect"/>
      </coding>
    </code>
    <valueCodeableConcept>
      <coding>
        <system value="http://www.sequenceontology.org"/>
        <code value="SO_0001786"/>
        <display value="loss_of_heterozygosity"/>
      </coding>
    </valueCodeableConcept>
  </component>
</Observation>