NHS North West Genomics
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Questionnaire: North West Genomics dWGS Sub-Order Manifest

Official URL: https://fhir.nwgenomics.nhs.uk/Questionnaire/dWGSSubOrder Version: 2.2.0
Draft as of 2026-09-20 Computable Name:

For analysis purposes only - not an active or planned project.

CSV manifest description, not an Ask At Order Entry Questionnaire - this Questionnaire documents the complete digital manifest for a distributed WGS (dWGS) sub-contracted order (IHE LTW LAB-35), sent by a Requesting Genomic Laboratory (RGL) to North West Genomics acting as Sequencing Genomic Laboratory (SGL): the 37 national digital manifest fields (NHS England RGL to SGL SOP Appendix 3) plus 5 local extension fields, with item.definition mappings to FHIR where a confirmed mapping exists - see dWGS. It deliberately carries every manifest field, including several also asked by Genomic Test Order (Patient name/DOB/NHS number, Specimen Type, Specimen Collection Date) - because it describes the full CSV structure a Requesting Genomic Laboratory actually sends, not an incremental set of order-entry questions. For the genuinely additional Ask At Order Entry content - the manifest fields not already covered by the common core - see dWGS Ask At Order Entry Questions, which derivedFrom/ extends Genomic Test Order in the usual way.

This Questionnaire is a CSV manifest description, not an Ask At Order Entry Questionnaire - it documents the complete 42-field digital manifest a Requesting Genomic Laboratory sends for a distributed WGS (dWGS) sub-contracted order, including several fields also asked by Genomic Test Order itself. See dWGS - Ask at Order Entry: the dWGS digital manifest for the full narrative, dWGS - Field mapping for the complete field-by-field CSV/HL7 v2/FHIR mapping, and dWGS Ask At Order Entry Questions for the genuinely additional Ask At Order Entry Questionnaire this manifest was split from.

Summary

Unlike the NW GLH Paper Test Request Forms, this Questionnaire genuinely does carry its own Patient/order-identifier fields directly (it doesn't rely on derivedFrom/extends Genomic Test Order for them) - see dWGS - Field mapping for the full 42-field table; the fields below are the identifying subset most comparable to what those other Ask At Order Entry Questionnaires' own Summary sections list:

Item CSV Field FHIR
Patient first/last name patient_forename/patient_surname Patient.name
Date of birth patient_date_of_birth Patient.birthDate
NHS Number patient_nhs_number Patient.identifier:nhsNumber
Patient Identifier (NGIS) patient_ngis_id Patient.identifier (assigner Genomics England, ODS 8J834)
Original Order Placer Group Number (Referral ID) referral_id ServiceRequest.requisition
Test Code clinical_indication_test_type_id ServiceRequest.code.coding (England-GenomicTestDirectory)
Original Ordering Facility Code ordering_entity_id Specimen.identifier.assigner.identifier.value
Filler Order Ordering Facility Code (GLH) glh_laboratory_id ServiceRequest.requester.identifier.value
Family Structure / Participant Type Singleton/Duo/Trio, Proband/Family Member Observation.valueCodeableConcept (ServiceRequest.supportingInfo)

Profile: Questionnaire

LinkIDTextCardinalityTypeDescription & Constraintsdoco
.. **For analysis purposes only - not an active or planned project.** **CSV manifest description**, not an Ask At Order Entry Questionnaire - this Questionnaire documents the complete digital manifest for a **distributed WGS (dWGS)** sub-contracted order (IHE LTW `LAB-35`), sent by a Requesting Genomic Laboratory (RGL) to North West Genomics acting as Sequencing Genomic Laboratory (SGL): the 37 national digital manifest fields (NHS England `RGL to SGL SOP` Appendix 3) plus 5 local extension fields, with `item.definition` mappings to FHIR where a confirmed mapping exists - see [dWGS](dWGS.html#field-mapping-csv--hl7-v2--fhir). It deliberately carries **every** manifest field, including several also asked by [Genomic Test Order](Questionnaire-GenomicTestOrder.html) (Patient name/DOB/NHS number, Specimen Type, Specimen Collection Date) - because it describes the full CSV structure a Requesting Genomic Laboratory actually sends, not an incremental set of order-entry questions. For the genuinely additional Ask At Order Entry content - the manifest fields **not** already covered by the common core - see [dWGS Ask At Order Entry Questions](Questionnaire-dWGSAskAtOrderEntry.html), which `derivedFrom`/ extends [Genomic Test Order](Questionnaire-GenomicTestOrder.html) in the usual way. Questionnaire https://fhir.nwgenomics.nhs.uk/Questionnaire/dWGSSubOrder#2.2.0
... Referral Referral / Sub-Order 0..1 group Definition: ServiceRequest
Value Set:
.... dWGS/referral_id Original Order Placer Group Number (Referral ID) 1..1 string Definition: ServiceRequest.requisition
Value Set:
.... dWGS/clinical_indication_test_type_id Test Code 0..1 choice Definition: ServiceRequest.code
Value Set: Genomic Test Codes
.... dWGS/ordering_entity_id Original Ordering Facility Code 0..1 string Definition: Specimen.identifier.assigner.identifier.value
Value Set:
..... dWGS/ordering_entity_id-designNote ODS code of the original referring Trust - assigner of the Received Sample Identifier (type=PLAC) below, not the same as the Filler Order Ordering Facility Code. 0..1 display Value Set:
.... dWGS/glh_laboratory_id Filler Order Ordering Facility Code (GLH) 1..1 string Definition: ServiceRequest.requester.identifier.value
Value Set:
..... dWGS/glh_laboratory_id-designNote A Genomic Laboratory Hub (GLH) ODS code, not the referring Trust's own ODS code - also assigns ServiceRequest.requisition and the Specimen's LIMS identifier (type=FILL). 0..1 display Value Set:
.... dWGS/retrospective_sample Retrospective Sample Flag 0..1 string Definition: ServiceRequest.intent
Value Set:
..... dWGS/retrospective_sample-designNote Values: "New" (ServiceRequest.intent = filler-order) or "Retrospective" (ServiceRequest.intent = reflex-order - NW Genomics is reflexing further testing off a specimen it already holds, not a fresh sub-order). 0..1 display Value Set:
.... dWGS/clinical_information Clinical Information 0..1 text Definition: ServiceRequest.note
Value Set:
.... dWGS/approved_by Approved By 0..1 string Value Set:
... Patient Patient 0..1 group Definition: Patient
Value Set:
.... LN/45392-8 Patient first name 1..1 string Definition: Patient.name.given
Value Set:
.... LN/45394-4 Patient surname 1..1 string Definition: Patient.name.family
Value Set:
.... LN/21112-8 Date of birth 1..1 date Definition: Patient.birthDate
Value Set:
.... LN/89061-6 NHS Number 0..1 string Definition: Patient.identifier:nhsNumber
Value Set:
.... dWGS/patient_ngis_id Patient Identifier (NGIS) 1..1 string Definition: Patient.identifier
Value Set:
..... dWGS/patient_ngis_id-designNote No confirmed identifier system - carried as Patient.identifier.assigner (Genomics England, ODS 8J834, who run NGIS), type=PI (v2-0203 Patient internal identifier). 0..1 display Value Set:
... AskAtOrderEntry Ask At Order Entry Questions 0..1 group Value Set:
.... NOS/FamilyStructure Family Structure 1..1 string Definition: Observation.valueCodeableConcept
Value Set:
..... NOS/FamilyStructure-designNote Values: "Singleton", "Duo" or "Trio" - how many people are being tested together as part of this referral. Text-only (no NW-GMSA-confirmed coding system exists), carried as an Observation referenced from ServiceRequest.supportingInfo. See [dWGS - Singleton, Duo and Trio testing](dWGS.html#singleton-duo-and-trio-testing). 0..1 display Value Set:
.... NOS/ParticipantType Participant Type 1..1 string Definition: Observation.valueCodeableConcept
Value Set:
..... NOS/ParticipantType-designNote Values: "Proband" or "Family Member" - this individual's role within the Family Structure above. Text-only, carried as an Observation referenced from ServiceRequest.supportingInfo. 0..1 display Value Set:
... PrimarySpecimen Primary Specimen (as received by GLH) 0..1 group Definition: Specimen
Value Set:
.... dWGS/primary_sample_received_date Sample Received Date 0..1 dateTime Definition: Specimen.receivedTime
Value Set:
.... dWGS/primary_sample_id_as_received_by_glh Received Sample Identifier 0..1 string Definition: Specimen.identifier
Value Set:
..... dWGS/primary_sample_id_as_received_by_glh-designNote Assigned by the Original Ordering Facility - coded type=PLAC (Placer Identifier). 0..1 display Value Set:
.... dWGS/primary_sample_id_in_glh_lims LIMS Sample Identifier 0..1 string Definition: Specimen.identifier
Value Set:
..... dWGS/primary_sample_id_in_glh_lims-designNote Assigned by the Filler Order Ordering Facility (GLH) - coded type=FILL (Filler Identifier). 0..1 display Value Set:
.... dWGS/primary_sample_type Sample Type 0..1 string Value Set:
..... dWGS/primary_sample_type-designNote Germline/tumour classifier - low confidence, no clean Specimen field identified; not currently built into any FHIR resource. 0..1 display Value Set:
.... LN/66746-9 Sample Material Type 0..1 choice Definition: Specimen.type.coding.code
Value Set: Specimen Type
.... dWGS/received_sample_topography Sample Topography 0..1 string Definition: Specimen.bodySite
Value Set:
..... dWGS/received_sample_topography-designNote Cancer referrals only. 0..1 display Value Set:
.... dWGS/received_sample_morphology Sample Morphology 0..1 string Value Set:
.... dWGS/received_sample_tumour_content_pct Tumour Content (%) 0..1 decimal Value Set:
..... dWGS/received_sample_tumour_content_pct-designNote Cancer referrals only. 0..1 display Value Set:
.... dWGS/received_sample_comments Sample Comments 0..1 string Value Set:
.... LN/33882-2 Specimen Collection Date 0..1 dateTime Definition: Specimen.collection.collectedDateTime
Value Set:
... DispatchedSpecimen Dispatched Specimen (extracted DNA sent onward) 0..1 group Definition: Specimen
Value Set:
.... dWGS/dispatched_sample_id_in_glh_lims Dispatched Sample Identifier 0..1 string Value Set:
.... dWGS/dispatched_sample_lsid Specimen Barcode 1..1 string Definition: Specimen.container.identifier
Value Set:
..... dWGS/dispatched_sample_lsid-designNote Carried on Specimen.container.identifier, coded type=ZCID - see NW IdentifierType. 0..1 display Value Set:
.... dWGS/dispatched_sample_type Dispatched Sample Type 0..1 string Value Set:
.... dWGS/dispatched_sample_state Dispatched Material Type 0..1 string Value Set:
..... dWGS/dispatched_sample_state-designNote Not currently built into any FHIR resource - the worked example's single Specimen only carries the primary specimen's Sample Material Type above. 0..1 display Value Set:
.... dWGS/dispatched_sample_volume_ul Sample Volume (uL) 0..1 decimal Definition: Specimen.collection.quantity
Value Set:
.... dWGS/dna_extraction_protocol DNA Extraction Method 0..1 string Definition: Specimen.collection.method
Value Set:
.... dWGS/glh_sample_consignment_number Consignment Number 0..1 string Definition: Specimen.identifier
Value Set:
..... dWGS/glh_sample_consignment_number-designNote Carried as a Specimen identifier, coded type=STN (Shipment Tracking Number). 0..1 display Value Set:
... LaboratoryQC Laboratory QC and Logistics 0..1 group Value Set:
.... dWGS/laboratory_remaining_volume_banked_ul Remaining Banked Volume (uL) 0..1 decimal Value Set:
.... dWGS/glh_concentration_ng_ul DNA Concentration (ng/uL) 0..1 decimal Value Set:
.... dWGS/glh_od260_280 DNA Purity (OD260/280) 0..1 decimal Value Set:
.... dWGS/glh_din_value DNA Integrity Number 0..1 decimal Value Set:
.... dWGS/glh_percentage_dna_over_23kb DNA Fragment Size (% over 23kb) 0..1 decimal Value Set:
.... dWGS/glh_qc_status QC Status 0..1 string Value Set:
.... dWGS/glh_sample_dispatch_date Dispatch Date 0..1 date Value Set:
.... dWGS/plating_organisation Plating Organisation 0..1 string Value Set:
.... dWGS/gmc_rack_id Rack Identifier 0..1 string Value Set:
.... dWGS/gmc_rack_well Rack Well Position 0..1 string Value Set:
..... dWGS/gmc_rack_well-designNote Pattern: [A-H]01-09 or [A-H]10-12. 0..1 display Value Set:
.... dWGS/prolonged_sample_storage Sample Storage Method 0..1 string Value Set:

doco Documentation for this format

Profile: Questionnaire

Referral / Sub-Order

Original Order Placer Group Number (Referral ID)*

Test Code

Original Ordering Facility Code

ODS code of the original referring Trust - assigner of the Received Sample Identifier (type=PLAC) below, not the same as the Filler Order Ordering Facility Code.

  • linkId: dWGS/ordering_entity_id-designNote
  • Answers:

Filler Order Ordering Facility Code (GLH)*

A Genomic Laboratory Hub (GLH) ODS code, not the referring Trust's own ODS code - also assigns ServiceRequest.requisition and the Specimen's LIMS identifier (type=FILL).

  • linkId: dWGS/glh_laboratory_id-designNote
  • Answers:

Retrospective Sample Flag

Values: "New" (ServiceRequest.intent = filler-order) or "Retrospective" (ServiceRequest.intent = reflex-order - NW Genomics is reflexing further testing off a specimen it already holds, not a fresh sub-order).

  • linkId: dWGS/retrospective_sample-designNote
  • Answers:

Clinical Information

Approved By

  • linkId: dWGS/approved_by
  • Answers:

Patient

  • linkId: Patient
  • Definition:: Patient
  • Answers:

Patient first name*

Patient surname*

Date of birth*

NHS Number

Patient Identifier (NGIS)*

No confirmed identifier system - carried as Patient.identifier.assigner (Genomics England, ODS 8J834, who run NGIS), type=PI (v2-0203 Patient internal identifier).

  • linkId: dWGS/patient_ngis_id-designNote
  • Answers:

Ask At Order Entry Questions

  • linkId: AskAtOrderEntry
  • Answers:

Family Structure*

Values: "Singleton", "Duo" or "Trio" - how many people are being tested together as part of this referral. Text-only (no NW-GMSA-confirmed coding system exists), carried as an Observation referenced from ServiceRequest.supportingInfo. See [dWGS - Singleton, Duo and Trio testing](dWGS.html#singleton-duo-and-trio-testing).

  • linkId: NOS/FamilyStructure-designNote
  • Answers:

Participant Type*

Values: "Proband" or "Family Member" - this individual's role within the Family Structure above. Text-only, carried as an Observation referenced from ServiceRequest.supportingInfo.

  • linkId: NOS/ParticipantType-designNote
  • Answers:

Primary Specimen (as received by GLH)

  • linkId: PrimarySpecimen
  • Definition:: Specimen
  • Answers:

Sample Received Date

Received Sample Identifier

Assigned by the Original Ordering Facility - coded type=PLAC (Placer Identifier).

  • linkId: dWGS/primary_sample_id_as_received_by_glh-designNote
  • Answers:

LIMS Sample Identifier

Assigned by the Filler Order Ordering Facility (GLH) - coded type=FILL (Filler Identifier).

  • linkId: dWGS/primary_sample_id_in_glh_lims-designNote
  • Answers:

Sample Type

  • linkId: dWGS/primary_sample_type
  • Answers:

Germline/tumour classifier - low confidence, no clean Specimen field identified; not currently built into any FHIR resource.

  • linkId: dWGS/primary_sample_type-designNote
  • Answers:

Sample Material Type

Sample Topography

Cancer referrals only.

  • linkId: dWGS/received_sample_topography-designNote
  • Answers:

Sample Morphology

  • linkId: dWGS/received_sample_morphology
  • Answers:

Tumour Content (%)

  • linkId: dWGS/received_sample_tumour_content_pct
  • Answers:

Cancer referrals only.

  • linkId: dWGS/received_sample_tumour_content_pct-designNote
  • Answers:

Sample Comments

  • linkId: dWGS/received_sample_comments
  • Answers:

Specimen Collection Date

Dispatched Specimen (extracted DNA sent onward)

  • linkId: DispatchedSpecimen
  • Definition:: Specimen
  • Answers:

Dispatched Sample Identifier

  • linkId: dWGS/dispatched_sample_id_in_glh_lims
  • Answers:

Specimen Barcode*

Carried on Specimen.container.identifier, coded type=ZCID - see NW IdentifierType.

  • linkId: dWGS/dispatched_sample_lsid-designNote
  • Answers:

Dispatched Sample Type

  • linkId: dWGS/dispatched_sample_type
  • Answers:

Dispatched Material Type

  • linkId: dWGS/dispatched_sample_state
  • Answers:

Not currently built into any FHIR resource - the worked example's single Specimen only carries the primary specimen's Sample Material Type above.

  • linkId: dWGS/dispatched_sample_state-designNote
  • Answers:

Sample Volume (uL)

DNA Extraction Method

Consignment Number

Carried as a Specimen identifier, coded type=STN (Shipment Tracking Number).

  • linkId: dWGS/glh_sample_consignment_number-designNote
  • Answers:

Laboratory QC and Logistics

  • linkId: LaboratoryQC
  • Answers:

Remaining Banked Volume (uL)

  • linkId: dWGS/laboratory_remaining_volume_banked_ul
  • Answers:

DNA Concentration (ng/uL)

  • linkId: dWGS/glh_concentration_ng_ul
  • Answers:

DNA Purity (OD260/280)

  • linkId: dWGS/glh_od260_280
  • Answers:

DNA Integrity Number

  • linkId: dWGS/glh_din_value
  • Answers:

DNA Fragment Size (% over 23kb)

  • linkId: dWGS/glh_percentage_dna_over_23kb
  • Answers:

QC Status

  • linkId: dWGS/glh_qc_status
  • Answers:

Dispatch Date

  • linkId: dWGS/glh_sample_dispatch_date
  • Answers:

Plating Organisation

  • linkId: dWGS/plating_organisation
  • Answers:

Rack Identifier

  • linkId: dWGS/gmc_rack_id
  • Answers:

Rack Well Position

  • linkId: dWGS/gmc_rack_well
  • Answers:

Pattern: [A-H]01-09 or [A-H]10-12.

  • linkId: dWGS/gmc_rack_well-designNote
  • Answers:

Sample Storage Method

  • linkId: dWGS/prolonged_sample_storage
  • Answers:

Profile: Questionnaire

LinkIDDescription & Constraintsdoco
.. Referral Definition: ServiceRequest
Value Set:
... dWGS/referral_id Definition: ServiceRequest.requisition
Value Set:
... dWGS/clinical_indication_test_type_id Definition: ServiceRequest.code
Value Set: Genomic Test Codes
... dWGS/ordering_entity_id Definition: Specimen.identifier.assigner.identifier.value
Value Set:
.... dWGS/ordering_entity_id-designNote Value Set:
... dWGS/glh_laboratory_id Definition: ServiceRequest.requester.identifier.value
Value Set:
.... dWGS/glh_laboratory_id-designNote Value Set:
... dWGS/retrospective_sample Definition: ServiceRequest.intent
Value Set:
.... dWGS/retrospective_sample-designNote Value Set:
... dWGS/clinical_information Definition: ServiceRequest.note
Value Set:
... dWGS/approved_by Value Set:
.. Patient Definition: Patient
Value Set:
... LN/45392-8 Definition: Patient.name.given
Value Set:
... LN/45394-4 Definition: Patient.name.family
Value Set:
... LN/21112-8 Definition: Patient.birthDate
Value Set:
... LN/89061-6 Definition: Patient.identifier:nhsNumber
Value Set:
... dWGS/patient_ngis_id Definition: Patient.identifier
Value Set:
.... dWGS/patient_ngis_id-designNote Value Set:
.. AskAtOrderEntry Value Set:
... NOS/FamilyStructure Definition: Observation.valueCodeableConcept
Value Set:
.... NOS/FamilyStructure-designNote Value Set:
... NOS/ParticipantType Definition: Observation.valueCodeableConcept
Value Set:
.... NOS/ParticipantType-designNote Value Set:
.. PrimarySpecimen Definition: Specimen
Value Set:
... dWGS/primary_sample_received_date Definition: Specimen.receivedTime
Value Set:
... dWGS/primary_sample_id_as_received_by_glh Definition: Specimen.identifier
Value Set:
.... dWGS/primary_sample_id_as_received_by_glh-designNote Value Set:
... dWGS/primary_sample_id_in_glh_lims Definition: Specimen.identifier
Value Set:
.... dWGS/primary_sample_id_in_glh_lims-designNote Value Set:
... dWGS/primary_sample_type Value Set:
.... dWGS/primary_sample_type-designNote Value Set:
... LN/66746-9 Definition: Specimen.type.coding.code
Value Set: Specimen Type
... dWGS/received_sample_topography Definition: Specimen.bodySite
Value Set:
.... dWGS/received_sample_topography-designNote Value Set:
... dWGS/received_sample_morphology Value Set:
... dWGS/received_sample_tumour_content_pct Value Set:
.... dWGS/received_sample_tumour_content_pct-designNote Value Set:
... dWGS/received_sample_comments Value Set:
... LN/33882-2 Definition: Specimen.collection.collectedDateTime
Value Set:
.. DispatchedSpecimen Definition: Specimen
Value Set:
... dWGS/dispatched_sample_id_in_glh_lims Value Set:
... dWGS/dispatched_sample_lsid Definition: Specimen.container.identifier
Value Set:
.... dWGS/dispatched_sample_lsid-designNote Value Set:
... dWGS/dispatched_sample_type Value Set:
... dWGS/dispatched_sample_state Value Set:
.... dWGS/dispatched_sample_state-designNote Value Set:
... dWGS/dispatched_sample_volume_ul Definition: Specimen.collection.quantity
Value Set:
... dWGS/dna_extraction_protocol Definition: Specimen.collection.method
Value Set:
... dWGS/glh_sample_consignment_number Definition: Specimen.identifier
Value Set:
.... dWGS/glh_sample_consignment_number-designNote Value Set:
.. LaboratoryQC Value Set:
... dWGS/laboratory_remaining_volume_banked_ul Value Set:
... dWGS/glh_concentration_ng_ul Value Set:
... dWGS/glh_od260_280 Value Set:
... dWGS/glh_din_value Value Set:
... dWGS/glh_percentage_dna_over_23kb Value Set:
... dWGS/glh_qc_status Value Set:
... dWGS/glh_sample_dispatch_date Value Set:
... dWGS/plating_organisation Value Set:
... dWGS/gmc_rack_id Value Set:
... dWGS/gmc_rack_well Value Set:
.... dWGS/gmc_rack_well-designNote Value Set:
... dWGS/prolonged_sample_storage Value Set:

doco Documentation for this format

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