NHS North West Genomics
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Questionnaire: Chimerism Testing Result Panel

Official URL: https://fhir.nwgenomics.nhs.uk/Questionnaire/ChimerismResultPanel Version: 2.2.0
Draft as of 2026-09-20 Computable Name:

Result panel for STR-based chimerism testing (Clatterbridge post-transplant monitoring) - see Histocompatibility and Immunogenetics - Chimerism Testing Result Panel (Future?) for the source data table this Questionnaire structures.

The payload described there is currently unstructured NTE/OBX text, with no FHIR mapping yet - item.definition values here are the same candidate mappings recorded in that table's "FHIR Genomic Report Field" column, most inferred by analogy with HL7's Genomics Reporting IG - Histocompatibility and Immunogenetic Reporting (a dependency of this IG, though it profiles HLA allele genotyping, not STR chimerism) rather than confirmed against a real example, unlike BCRABLResultPanel which is inferred from real Observation examples. Several rows have no direct FHIR fit and are marked as such rather than forced onto one.

Profile: Questionnaire

LinkIDTextCardinalityTypeDescription & Constraintsdoco
.. Result panel for STR-based chimerism testing (Clatterbridge post-transplant monitoring) - see [Histocompatibility and Immunogenetics - Chimerism Testing Result Panel (Future?)](HistocompatibilityAndImmunogenetics.html#chimerism-testing-result-panel-future) for the source data table this Questionnaire structures. The payload described there is currently unstructured `NTE`/`OBX` text, with no FHIR mapping yet - `item.definition` values here are the same candidate mappings recorded in that table's "FHIR Genomic Report Field" column, most inferred by analogy with [HL7's Genomics Reporting IG - Histocompatibility and Immunogenetic Reporting](http://hl7.org/fhir/uv/genomics-reporting/histocompatibility.html) (a dependency of this IG, though it profiles HLA allele genotyping, not STR chimerism) rather than confirmed against a real example, unlike [BCRABLResultPanel](Questionnaire-BCRABLResultPanel.html) which is inferred from real `Observation` examples. Several rows have no direct FHIR fit and are marked as such rather than forced onto one. Questionnaire https://fhir.nwgenomics.nhs.uk/Questionnaire/ChimerismResultPanel#2.2.0
... Report Chimerism Report 0..1 group Definition: DiagnosticReport
Value Set:
.... Chimerism/TestMethod Test Method 0..1 string Definition: DiagnosticReport.method
Value Set:
..... Chimerism/TestMethod-designNote e.g. "Chimerism analysis by STR technique." No local code (NTE, unstructured) - candidate mapping only, DiagnosticReport.method is not otherwise used in this IG. 0..1 display Value Set:
.... Chimerism/Device Device 0..1 string Definition: Device
Value Set:
..... Chimerism/Device-designNote e.g. "Test performed using Promega GenePrint 24 kit." No local code (NTE, unstructured) - candidate mapping only, referenced from DiagnosticReport or Observation.device. 0..1 display Value Set:
.... Result Chimerism Result 0..1 group Definition: DiagnosticReport.result
Value Set:
..... Chimerism/AverageChimerism Average % Chimerism 0..1 decimal Definition: Observation.valueQuantity
Value Set:
..... Chimerism/InformativeMarkers Informative Markers 0..1 string Definition: MolecularSequence
Value Set:
...... Chimerism/InformativeMarkers-designNote e.g. "D13S317 PENTA E CSF1PO PENTA D D21S11 D8S1179 D12S391" - the STR loci examined. Candidate mapping: the same role a Haplotype Observation's MolecularSequence evidence plays for HLA alleles, but for STR loci. 0..1 display Value Set:
..... Chimerism/Range Range 0..1 string Definition: Observation.referenceRange
Value Set:
..... Chimerism/CV CV 0..1 string Definition: Observation.component
Value Set:
...... Chimerism/CV-designNote Coefficient of variation - a QC metric, not profiled by the Histocompatibility Reporting page. 0..1 display Value Set:
.... Specimen Specimen 0..1 group Definition: Specimen
Value Set:
..... Chimerism/ExtractionMethod Extraction Method 0..1 string Definition: Specimen.collection.method
Value Set:
...... Chimerism/ExtractionMethod-designNote e.g. "DNA extracted from peripheral blood leukocyte" - the same field dWGS's dna_extraction_protocol uses, see dWGS field mapping. 0..1 display Value Set:
..... Chimerism/Purity % Purity 0..1 decimal Value Set:
...... Chimerism/Purity-designNote Specimen quality metric - not profiled by the Histocompatibility Reporting page. No definition mapping - low confidence, free text/number only. 0..1 display Value Set:
.... ClinicalContext Clinical Context 0..1 group Value Set:
..... Chimerism/TimePostTransplant Time Post Transplant 0..1 string Definition: Observation.valueString
Value Set:
...... Chimerism/TimePostTransplant-designNote e.g. "2YR 7 MONTHS" - carried as an Observation referenced from ServiceRequest.supportingInfo, the same Ask at Order Entry pattern used elsewhere in this IG (dWGS's Family Structure/Participant Type). 0..1 display Value Set:
..... Chimerism/DateOfTransplant Date of Transplant 0..1 date Definition: Procedure.performedDateTime
Value Set:
...... Chimerism/DateOfTransplant-designNote The transplant event itself - outside the Histocompatibility Reporting page's scope, which starts from the genotyping result, not the clinical transplant history. 0..1 display Value Set:
..... Chimerism/DonorID Donor ID 0..1 string Definition: Specimen.identifier
Value Set:
...... Chimerism/DonorID-designNote e.g. "6939 DKM0 0096 2141 100" - the same identifier-on-Specimen pattern dWGS uses for its PLAC/FILL identifiers; could alternatively be a reference to the donor's own Patient resource. 0..1 display Value Set:

doco Documentation for this format

Profile: Questionnaire

Chimerism Report

Test Method

e.g. "Chimerism analysis by STR technique." No local code (NTE, unstructured) - candidate mapping only, DiagnosticReport.method is not otherwise used in this IG.

  • linkId: Chimerism/TestMethod-designNote
  • Answers:

Device

  • linkId: Chimerism/Device
  • Definition:: Device
  • Answers:

e.g. "Test performed using Promega GenePrint 24 kit." No local code (NTE, unstructured) - candidate mapping only, referenced from DiagnosticReport or Observation.device.

  • linkId: Chimerism/Device-designNote
  • Answers:

Chimerism Result

Average % Chimerism

Informative Markers

e.g. "D13S317 PENTA E CSF1PO PENTA D D21S11 D8S1179 D12S391" - the STR loci examined. Candidate mapping: the same role a Haplotype Observation's MolecularSequence evidence plays for HLA alleles, but for STR loci.

  • linkId: Chimerism/InformativeMarkers-designNote
  • Answers:

Range

CV

Coefficient of variation - a QC metric, not profiled by the Histocompatibility Reporting page.

  • linkId: Chimerism/CV-designNote
  • Answers:

Specimen

  • linkId: Specimen
  • Definition:: Specimen
  • Answers:

Extraction Method

e.g. "DNA extracted from peripheral blood leukocyte" - the same field dWGS's dna_extraction_protocol uses, see dWGS field mapping.

  • linkId: Chimerism/ExtractionMethod-designNote
  • Answers:

% Purity

  • linkId: Chimerism/Purity
  • Answers:

Specimen quality metric - not profiled by the Histocompatibility Reporting page. No definition mapping - low confidence, free text/number only.

  • linkId: Chimerism/Purity-designNote
  • Answers:

Clinical Context

  • linkId: ClinicalContext
  • Answers:

Time Post Transplant

e.g. "2YR 7 MONTHS" - carried as an Observation referenced from ServiceRequest.supportingInfo, the same Ask at Order Entry pattern used elsewhere in this IG (dWGS's Family Structure/Participant Type).

  • linkId: Chimerism/TimePostTransplant-designNote
  • Answers:

Date of Transplant

The transplant event itself - outside the Histocompatibility Reporting page's scope, which starts from the genotyping result, not the clinical transplant history.

  • linkId: Chimerism/DateOfTransplant-designNote
  • Answers:

Donor ID

e.g. "6939 DKM0 0096 2141 100" - the same identifier-on-Specimen pattern dWGS uses for its PLAC/FILL identifiers; could alternatively be a reference to the donor's own Patient resource.

  • linkId: Chimerism/DonorID-designNote
  • Answers:

Profile: Questionnaire

LinkIDDescription & Constraintsdoco
.. Report Definition: DiagnosticReport
Value Set:
... Chimerism/TestMethod Definition: DiagnosticReport.method
Value Set:
.... Chimerism/TestMethod-designNote Value Set:
... Chimerism/Device Definition: Device
Value Set:
.... Chimerism/Device-designNote Value Set:
... Result Definition: DiagnosticReport.result
Value Set:
.... Chimerism/AverageChimerism Definition: Observation.valueQuantity
Value Set:
.... Chimerism/InformativeMarkers Definition: MolecularSequence
Value Set:
..... Chimerism/InformativeMarkers-designNote Value Set:
.... Chimerism/Range Definition: Observation.referenceRange
Value Set:
.... Chimerism/CV Definition: Observation.component
Value Set:
..... Chimerism/CV-designNote Value Set:
... Specimen Definition: Specimen
Value Set:
.... Chimerism/ExtractionMethod Definition: Specimen.collection.method
Value Set:
..... Chimerism/ExtractionMethod-designNote Value Set:
.... Chimerism/Purity Value Set:
..... Chimerism/Purity-designNote Value Set:
... ClinicalContext Value Set:
.... Chimerism/TimePostTransplant Definition: Observation.valueString
Value Set:
..... Chimerism/TimePostTransplant-designNote Value Set:
.... Chimerism/DateOfTransplant Definition: Procedure.performedDateTime
Value Set:
..... Chimerism/DateOfTransplant-designNote Value Set:
.... Chimerism/DonorID Definition: Specimen.identifier
Value Set:
..... Chimerism/DonorID-designNote Value Set:

doco Documentation for this format

Test this Questionnaire

Try this questionnaire out:

Responses for this Questionnaire

There are currently no QuestionnaireResponse instances for this Questionnaire defined in this IG.