NHS North West Genomics
2.2.0 - ci-build
NHS North West Genomics
2.2.0 - ci-build
NHS North West Genomics - Local Development build (v2.2.0) built by the FHIR (HL7® FHIR® Standard) Build Tools. See the Directory of published versions
{
"resourceType" : "Bundle",
"id" : "Shire2StructuredR01",
"language" : "en",
"identifier" : {
"value" : "SHIRE:CPP:RTST-260416-0"
},
"type" : "message",
"timestamp" : "2026-04-16T10:38:39+00:00",
"entry" : [
{
"fullUrl" : "urn:uuid:45a1d9f7-aebc-4e5c-bc88-6a39632bc2af",
"resource" : {
"resourceType" : "MessageHeader",
"language" : "en",
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"MessageHeader_null\"> </a><p class=\"res-header-id\"><b>Generated Narrative: MessageHeader </b></p><p><b>event</b>: <a href=\"http://terminology.hl7.org/7.3.0/CodeSystem-v2-0003.html#v2-0003-R01\">event: R01</a> (ORU/ACK - Unsolicited transmission of an observation message)</p><h3>Destinations</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Endpoint</b></td><td><b>Receiver</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://simplifier.net/resolve?scope=fhir.r4.ukcore.stu3.currentbuild@0.29.0-pre-release&canonical=http://fhir.org/packages/fhir.r4.ukcore.stu3.currentbuild/https//fhir.mft.nhs.uk/Endpoint/HODS\">https//fhir.mft.nhs.uk/Endpoint/HODS</a></td><td>Identifier: <a href=\"NamingSystem-ods-organization-code-namingsystem.html\" title=\"The identifier system for an Organisation registered with the Organisation Data Service (ODS).\">ODS Organisation Code</a>/HODS</td></tr></table><p><b>sender</b>: Identifier: <a href=\"NamingSystem-ods-organization-code-namingsystem.html\" title=\"The identifier system for an Organisation registered with the Organisation Data Service (ODS).\">ODS Organisation Code</a>/CPP</p><h3>Sources</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Software</b></td><td><b>Endpoint</b></td></tr><tr><td style=\"display: none\">*</td><td>NW GLH</td><td><a href=\"https://simplifier.net/resolve?scope=fhir.r4.ukcore.stu3.currentbuild@0.29.0-pre-release&canonical=https://fhir.nwgenomics.nhs.uk/Endpoint/SHIRE\">https://fhir.nwgenomics.nhs.uk/Endpoint/SHIRE</a></td></tr></table><p><b>focus</b>: <a href=\"Bundle-Shire2StructuredR01.html#urn-uuid-2ebb9c8d-eb68-42cc-ab53-c07f55869788\">Diagnostic Report for 'Karyotype [Identifier] in Bone marrow Nominal' for '->NED LIVERPOOL Unknown, DoB: 1942-06-18 ( National Health Plan Identifier)'</a></p></div>"
},
"eventCoding" : {
"system" : "http://terminology.hl7.org/CodeSystem/v2-0003",
"code" : "R01"
},
"destination" : [
{
"endpoint" : "https//fhir.mft.nhs.uk/Endpoint/HODS",
"receiver" : {
"identifier" : {
"system" : "https://fhir.nhs.uk/Id/ods-organization-code",
"value" : "HODS"
}
}
}
],
"sender" : {
"identifier" : {
"system" : "https://fhir.nhs.uk/Id/ods-organization-code",
"value" : "CPP"
}
},
"source" : {
"software" : "NW GLH",
"endpoint" : "https://fhir.nwgenomics.nhs.uk/Endpoint/SHIRE"
},
"focus" : [
{
"reference" : "urn:uuid:2ebb9c8d-eb68-42cc-ab53-c07f55869788"
}
]
}
},
{
"fullUrl" : "urn:uuid:52f677f9-6ab0-4a95-8b68-8b12762eedfb",
"resource" : {
"resourceType" : "Patient",
"language" : "en",
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Patient_null\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Patient </b></p><p style=\"border: 1px #661aff solid; background-color: #e6e6ff; padding: 10px;\">NED LIVERPOOL Unknown, DoB: 1942-06-18 ( National Health Plan Identifier)</p><hr/><table class=\"grid\"><tr><td style=\"background-color: #f3f5da\" title=\"Other Id (see the one above)\">Other Id:</td><td colspan=\"3\">Patient internal identifier/00123456789</td></tr></table></div>"
},
"identifier" : [
{
"extension" : [
{
"url" : "https://fhir.hl7.org.uk/StructureDefinition/Extension-UKCore-NHSNumberVerificationStatus",
"valueCodeableConcept" : {
"coding" : [
{
"system" : "https://fhir.hl7.org.uk/CodeSystem/UKCore-NHSNumberVerificationStatusEngland",
"code" : "05",
"display" : "Trace needs to be resolved - (NHS number or patient detail conflict)"
}
]
}
}
],
"type" : {
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/v2-0203",
"code" : "NH"
}
]
},
"system" : "https://fhir.nhs.uk/Id/nhs-number",
"value" : "9737383206"
},
{
"type" : {
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/v2-0203",
"code" : "PI"
}
]
},
"value" : "00123456789"
}
],
"name" : [
{
"family" : "LIVERPOOL",
"given" : [
"NED"
]
}
],
"gender" : "unknown",
"birthDate" : "1942-06-18"
}
},
{
"fullUrl" : "urn:uuid:7b14e763-b7a6-49de-9686-2fcd0e1da322",
"resource" : {
"resourceType" : "Observation",
"language" : "en",
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_null\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation </b></p><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 62356-1}\">Chromosome analysis result in ISCN expression</span></p><p><b>subject</b>: <a href=\"Bundle-Shire2StructuredR01.html#urn-uuid-52f677f9-6ab0-4a95-8b68-8b12762eedfb\">NED LIVERPOOL Unknown, DoB: 1942-06-18 ( National Health Plan Identifier)</a></p><p><b>value</b>: 48~50,XY,+X,-Y,-3,-6,-7,del(7)(q?31q36),+8,+11,add(12)(p11.2),+14,+15,-16,+19,+20,+22-,+1~2mar[cp10]</p><p><b>note</b>: </p><blockquote><div><p>48\\R\\50,XY,+X,-Y,-3,-6,-7,del(7)(q?31q36),+8,+11,add(12)(p11.2),+14,+15,-16,+19,+20,+22- ,+1\\R\\2mar[cp10] -Amendment 14/10/20</p>\n</div></blockquote></div>"
},
"status" : "final",
"category" : [
{
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/observation-category",
"code" : "laboratory"
}
]
}
],
"code" : {
"coding" : [
{
"system" : "http://loinc.org",
"code" : "62356-1",
"display" : "Chromosome analysis result in ISCN expression"
}
]
},
"subject" : {
"reference" : "urn:uuid:52f677f9-6ab0-4a95-8b68-8b12762eedfb"
},
"valueString" : "48~50,XY,+X,-Y,-3,-6,-7,del(7)(q?31q36),+8,+11,add(12)(p11.2),+14,+15,-16,+19,+20,+22-,+1~2mar[cp10]",
"note" : [
{
"text" : "48\\R\\50,XY,+X,-Y,-3,-6,-7,del(7)(q?31q36),+8,+11,add(12)(p11.2),+14,+15,-16,+19,+20,+22- ,+1\\R\\2mar[cp10] -Amendment 14/10/20"
}
]
}
},
{
"fullUrl" : "urn:uuid:b6fedd0a-7cf6-4308-948e-5c9531ccda0d",
"resource" : {
"resourceType" : "Observation",
"language" : "en",
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_null\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation </b></p><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 62367-8}\">Chromosome analysis panel by FISH</span></p><p><b>subject</b>: <a href=\"Bundle-Shire2StructuredR01.html#urn-uuid-52f677f9-6ab0-4a95-8b68-8b12762eedfb\">NED LIVERPOOL Unknown, DoB: 1942-06-18 ( National Health Plan Identifier)</a></p><p><b>value</b>: 7q deletion detected.</p><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:\">Interphase cells positive</span></p><p><b>value</b>: 93 cells</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 62361-1}\">Cells counted [#]</span></p><p><b>value</b>: 100 cells</p></blockquote></div>"
},
"status" : "final",
"category" : [
{
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/observation-category",
"code" : "laboratory"
}
]
}
],
"code" : {
"coding" : [
{
"system" : "http://loinc.org",
"code" : "62367-8",
"display" : "Chromosome analysis panel by FISH"
}
]
},
"subject" : {
"reference" : "urn:uuid:52f677f9-6ab0-4a95-8b68-8b12762eedfb"
},
"valueString" : "7q deletion detected.",
"component" : [
{
"code" : {
"text" : "Interphase cells positive"
},
"valueQuantity" : {
"value" : 93,
"unit" : "cells"
}
},
{
"code" : {
"coding" : [
{
"system" : "http://loinc.org",
"code" : "62361-1",
"display" : "Cells counted [#]"
}
]
},
"valueQuantity" : {
"value" : 100,
"unit" : "cells"
}
}
]
}
},
{
"fullUrl" : "urn:uuid:d54744fb-f490-44a1-90a0-1bfbce716fc5",
"resource" : {
"resourceType" : "Observation",
"language" : "en",
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_null\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation </b></p><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 62389-2}\">Chromosome analysis master panel</span></p><p><b>subject</b>: <a href=\"Bundle-Shire2StructuredR01.html#urn-uuid-52f677f9-6ab0-4a95-8b68-8b12762eedfb\">NED LIVERPOOL Unknown, DoB: 1942-06-18 ( National Health Plan Identifier)</a></p><p><b>hasMember</b>: </p><ul><li><a href=\"Bundle-Shire2StructuredR01.html#urn-uuid-7b14e763-b7a6-49de-9686-2fcd0e1da322\">Observation Chromosome analysis result in ISCN expression</a></li><li><a href=\"Bundle-Shire2StructuredR01.html#urn-uuid-b6fedd0a-7cf6-4308-948e-5c9531ccda0d\">Observation Chromosome analysis panel by FISH</a></li></ul></div>"
},
"status" : "final",
"category" : [
{
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/observation-category",
"code" : "laboratory"
}
]
}
],
"code" : {
"coding" : [
{
"system" : "http://loinc.org",
"code" : "62389-2",
"display" : "Chromosome analysis master panel"
}
]
},
"subject" : {
"reference" : "urn:uuid:52f677f9-6ab0-4a95-8b68-8b12762eedfb"
},
"hasMember" : [
{
"reference" : "urn:uuid:7b14e763-b7a6-49de-9686-2fcd0e1da322"
},
{
"reference" : "urn:uuid:b6fedd0a-7cf6-4308-948e-5c9531ccda0d"
}
]
}
},
{
"fullUrl" : "urn:uuid:2ebb9c8d-eb68-42cc-ab53-c07f55869788",
"resource" : {
"resourceType" : "DiagnosticReport",
"language" : "en",
"text" : {
"status" : "generated",
"div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"DiagnosticReport_null\"> </a><p class=\"res-header-id\"><b>Generated Narrative: DiagnosticReport </b></p><h2><span title=\"Codes:{http://loinc.org 33893-9}\">Karyotype [Identifier] in Bone marrow Nominal</span> (<span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span>) </h2><table class=\"grid\"><tr><td>Subject</td><td>NED LIVERPOOL Unknown, DoB: 1942-06-18 ( National Health Plan Identifier)</td></tr></table><p><b>Report Details</b></p><table class=\"grid\"><tr><td><b>Code</b></td><td><b>Value</b></td><td><b>Flags</b></td></tr><tr><td><a href=\"Bundle-Shire2StructuredR01.html#urn-uuid-d54744fb-f490-44a1-90a0-1bfbce716fc5\"><span title=\"Codes:{http://loinc.org 62389-2}\">Chromosome analysis master panel</span></a></td><td/><td>Final</td></tr></table><p>Complex abnormal hyperdiploid karyotype with gains of chromosomes 8 and\n11, and loss of 7q and 12p which are recognised findings in myeloid neoplasms\nincluding AML</p></div>"
},
"status" : "corrected",
"category" : [
{
"coding" : [
{
"system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
"code" : "GE"
}
]
}
],
"code" : {
"coding" : [
{
"system" : "http://loinc.org",
"code" : "33893-9",
"display" : "Karyotype [Identifier] in Bone marrow Nominal"
}
]
},
"subject" : {
"reference" : "urn:uuid:52f677f9-6ab0-4a95-8b68-8b12762eedfb"
},
"result" : [
{
"reference" : "urn:uuid:d54744fb-f490-44a1-90a0-1bfbce716fc5"
}
],
"conclusion" : "Complex abnormal hyperdiploid karyotype with gains of chromosomes 8 and\n11, and loss of 7q and 12p which are recognised findings in myeloid neoplasms\nincluding AML"
}
}
]
}