Bundle GenomicsReportMessage-ctDNA of type message

Entry 1 - fullUrl = urn:uuid:d63688c2-cd33-4cf1-8189-5cc2020333a3

Resource MessageHeader:

Last updated: 2026-07-13 10:39:26+0000; Language: en

Profile: Document Message (MessageHeader)

event: event: R01 (ORU/ACK - Unsolicited transmission of an observation message)

Destinations

-	Receiver
*	NEY GMSA (Identifier: ODS Organisation Code/699N0)

Sources

-	Software
*	NW GMSA

focus: Diagnostic Report for 'Genetic report' for '->Theon SHEFFIELD'

Entry 2 - fullUrl = urn:uuid:2160525b-0168-4f40-8ebf-9b053052a62c

Resource Patient:

Language: en

Profile: Patient

Theon SHEFFIELD (official) Male, DoB: 1986-09-12 ( Patient internal identifier: 336292)

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Active:	true
Other Id:	National Health Plan Identifier/9737873858 (use: official)
Contact Detail	SPITAL STREET SHEFFIELD S3 9LB (home)
Links:	General Practitioner: Sheffield Medical Centre (Identifier: ODS Organisation Code/C88622)

Entry 3 - fullUrl = urn:uuid:0a6ad8ec-b069-4a65-8c65-c7569d8413e3

Resource DiagnosticReport:

version: 1.0; Language: en

Profile: Diagnostic Report

Genetic report (Genetics)

Subject	Theon SHEFFIELD (official) Male, DoB: 1986-09-12 ( Patient internal identifier: 336292)
Relevant Time	2025-10-14 15:59:16+0000
Performer	NW GMSA (Identifier: ODS Organisation Code/699X0)
Identifier	https://fhir.nwgenomics.nhs.uk/iGene/ReportIdentifier/T26-59XG
Presented Form	application/pdf @ urn:uuid:d6eeedd1-92d3-45b9-bf33-6401e804425f

Report Details

Code	Value	Flags	Note	Relevant Time
Genetic variant assessment	Present	Final	ILLUSTRATIVE VALUES ONLY. The allelic frequency component (81258-6) is the field of primary clinical interest for a dPCR ctDNA result: it carries the mutant-allele fraction quantified directly by the assay (droplet/bead-positive fraction, Poisson-corrected), which is what a clinician uses to gauge ctDNA burden and track it serially — analogous to how VAF is used from NGS, but here derived from a targeted few-plex assay rather than sequencing depth.	2026-07-13 10:37:26+0000

Coded Conclusions:

• No display for DiagnosticReport.conclusionCode

Entry 4 - fullUrl = urn:uuid:6e26d6b3-490e-4348-9d6c-37281567d6ec

Resource ServiceRequest:

version: 1.0; Language: en

Profile: ServiceRequest

identifier: Filler Identifier/T26-59XG

requisition: Placer Group Number/R26-15AY

status: Active

intent: Order

category: Molecular genetics procedure

code: No display for ServiceRequest.code (concept: Non-Small Cell Lung Cancer, Multi-target ctDNA combined Multi-target NGS panel - small variant (EGFR, ALK, BRAF, KRAS, MET exon 14 skipping and copy number variations) and structural variant (ROS1, RET, ALK, NTRK1, NTRK2, NTRK3, MET exon 14 skipping))

subject: Theon SHEFFIELD

requester: Sheffield Lung Doctor at id: https://fhir.nhs.uk/Id/ods-organization-code#ODS Organisation Code#RHQ

performer: Identifier: ODS Organisation Code/699X0

Entry 5 - fullUrl = urn:uuid:4446ab81-35ef-49cb-b2fe-1d6f1a0dcc02

Resource PractitionerRole:

Language: en

Profile: PractitionerRole

Sheffield Lung Doctor at id: https://fhir.nhs.uk/Id/ods-organization-code#ODS Organisation Code#RHQ

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Practitioner:	Sheffield Lung Doctor (Identifier: GMC Number/C9999998)
Organization:	Identifier: ODS Organisation Code/RHQ
Specialty:	General Surgery